Compound ID | 2947

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Antibiotic 2093

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, vancomycin intermediate Staphylococcus aureus, Enterococcus faecalis, vancomycin-resistant and -susceptible Enterococcus faecium, Staphylococcus epidermidis, and Streptococcus pyogenes; aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor)
Description: Synthetic compound
Institute where first reported: Department of Medicine, University of Washington, Seattle, Washington, USA
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 432.3
Iso. SMILES: ClC1=CC(OC)=CC=C1CC2=CN(CC3=NC=4C=CC(Cl)=NC4N3)C(N2CC)=O
InChI Key: RDYREYRDYHMQKI-UHFFFAOYSA-N
Can. SMILES: CCN1C(=CN(CC2=NC3=C(N=C(C=C3)Cl)N2)C1=O)CC4=CC=C(C=C4Cl)OC
InChI: InChI=1S/C20H19Cl2N5O2/c1-3-27-13(8-12-4-5-14(29-2)9-15(12)21)10-26(20(27)28)11-18-23-16-6-7-17(22)24-19(16)25-18/h4-7,9-10H,3,8,11H2,1-2H3,(H,23,24,25)
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.00999-17

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