Compound ID | 2948

Update compound information

Antibiotic 2144

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, vancomycin intermediate Staphylococcus aureus, Enterococcus faecalis, vancomycin-resistant and -susceptible Enterococcus faecium, Staphylococcus epidermidis, and Streptococcus pyogenes; aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor)
Description: Synthetic compound
Institute where first reported: Department of Medicine, University of Washington, Seattle, Washington, USA
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 454.31
Iso. SMILES: ClC1=C(C2=CC=CC3=NC(CC4=NC=5C=CC(Cl)=NC5N4)=CN32)C=C(OC)C(OC)=C1
InChI Key: NRMDNEYEBUBFSW-UHFFFAOYSA-N
Can. SMILES: COC1=CC(=C(C=C1OC)Cl)C2=CC=CC3=NC(=CN23)CC4=NC5=C(N=C(C=C5)Cl)N4
InChI: InChI=1S/C22H17Cl2N5O2/c1-30-17-9-13(14(23)10-18(17)31-2)16-4-3-5-21-25-12(11-29(16)21)8-20-26-15-6-7-19(24)27-22(15)28-20/h3-7,9-11H,8H2,1-2H3,(H,26,27,28)
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.00999-17

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.