Compound ID | 2949

Update compound information

MPC-1

Class: Beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Class C beta-lactamases inhibitor
Target Pathogen: Active against class C beta-lactamase producing strains
Description: Synthetic compound; no intrinsic antibacterial activity; potentiates ampicillin and penicillin G
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 340.44
Iso. SMILES: O[C@@H]([C@@]1([H])C(N2[C@@H](C([O-])=O)C(C)(C)S[C@@]21[H])=O)CCC3=CC=CS3
InChI Key: SGRMPWFDGGTPCS-MPPDQPJWSA-M
Can. SMILES: CC1(C)[C@H](C(=O)[O-])N2C(=O)[C@]([H])([C@@H](CCC3=CC=CS3)O)[C@@]2([H])S1
InChI: InChI=1S/C15H19NO4S2/c1-15(2)11(14(19)20)16-12(18)10(13(16)22-15)9(17)6-5-8-4-3-7-21-8/h3-4,7,9-11,13,17H,5-6H2,1-2H3,(H,19,20)/p-1/t9-,10+,11+,13-/m1/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.01288-17

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