Compound ID | 295

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J-111,225

Synonym(s): J111225  |  J-111225  |  J 111225

Class: Beta-lactam (carbapenem)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Similar activity against P. aeruginosa as biapenem but improved MIC against MRSA (26 strains) compared to imipenem, meropenem and biapenem
Description: Adachi Y, Nagano R, Shibata K, et al. In vitro activities of J-111225, J-114870 and J-114871, novel carbapenems having potent activities against MRSA and Pseudomonas aeruginosa. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 246. Shimizu, A., Sugimoto, Y., Sakuraba, S., Imamura, H., Sato, H., Ohtake, R. et al. (1998). Novel trans-3,5-disubsituted pyrrolidinylthio 1β-methylcarbapenems with potent activity against MRSA and Pseudomonas aeruginosa. In Program and Abstracts of the Thirty-Eighth Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA. Abstract F-052, p. 246. American Society for Microbiology, Washington DC.
Institute where first reported: Banyu Pharmaceutical Co., Japan
Year first mentioned: 1998
Highest developmental phase: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 431.55
Iso. SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@@H](NC3)C4=CC=C(C=C4)CNC)C(=O)O)[C@@H](C)O
InChI Key: ZYCHALGBMHRNST-ZOQTURJOSA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]3C[C@H](C4=CC=C(C=C4)CNC)NC3)C(=O)O
InChI: InChI=1S/C22H29N3O4S/c1-11-18-17(12(2)26)21(27)25(18)19(22(28)29)20(11)30-15-8-16(24-10-15)14-6-4-13(5-7-14)9-23-3/h4-7,11-12,15-18,23-24,26H,8-10H2,1-3H3,(H,28,29)/t11-,12-,15+,16-,17-,18-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6918432
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/53/3/53_3_314/_article
  • https://academic.oup.com/jac/article/45/3/271/835914?login=true

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