Compound ID | 2952

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SPI009 (1-((2,4-dichlorophenethyl)amino)-3-phenoxypropan-2-ol)

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Membrane-active agent
Target Pathogen: Active against Pseudomonas aeruginosa
Description: Synthetic compound; analogue of a compound initially identified to show anti-persister activity from screening a small molecule library; reduces Pseudomonas aeruginosa persister cells in combination with ofloxacin (vs ofloxacin alone); shows intrinsic antibacterial activity (including persister cells); shows no haemolytic activity at 34 ug/ml (highest tested); shows cytotoxicity towards embryonic kidney HEK293T cells at IC50 32 ug/ml; eradicates cells when in combination with amikacin and ceftazidime
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 340.24
Iso. SMILES: C1=CC=C(C=C1)OCC(CNCCC2=C(C=C(C=C2)Cl)Cl)O
InChI Key: JCAAXTHZODTZFD-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2Cl)Cl)O
InChI: InChI=1S/C17H19Cl2NO2/c18-14-7-6-13(17(19)10-14)8-9-20-11-15(21)12-22-16-4-2-1-3-5-16/h1-7,10,15,20-21H,8-9,11-12H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3603560
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809444/
  • https://journals.asm.org/doi/10.1128/aac.00836-17

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