Compound ID | 2953
Cyclic lipopeptide 4 (CLP-4)
Class: Lipopeptide
| Agent Type: | Semisynthetic; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Unknown |
| Target Pathogen: | Active against Streptococcus mutans |
| Propensity to select resistant mutants: | No |
| Description: | Semisynthetic compound derived from fusaricidin; active against established biofilm and inhibits biofilm formation; shows 9% haemolytic activity towards human red blood cells at 1000 ug/ml (highest concentration tested); shows cytotoxicity (20.4% reduction in cell viability) towards human oral fibroblasts at 51 ug/ml (vs 2-5 ug/ml MIC) |
| Year first mentioned: | 2017 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.00776-17 |
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