Compound ID | 2954

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LPC-069

Class: Lipopolysaccharide synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Lipopolysaccharide synthesis inhibitor. LpxC inhibitor
Target Pathogen: Active against Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Proteus mirabilis, Citrobacter koseri, Citrobacter freundii, Serratia marcescens, Morganella morganii, Yersinia spp., Shigella spp., Salmonella spp., Pseudomonas aeruginosa, and Acinetobacter baumannii
Description: Synthetic compound; a morpholine-substituted biphenylacetylene molecule with difluoromethyl-l-allo-threonyl-hydroxamate head group; shows no tissue damage or effect to renal and hepatic function in plague infection in mice
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 487.5
Iso. SMILES: O=C(NC([C@@](C)(C(F)F)O)C(NO)=O)C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3
InChI Key: QNQLYOFTAZBSGC-QBGQUKIHSA-N
Can. SMILES: C[C@](C(C(=O)NO)NC(=O)C1=CC=C(C#CC2=CC=C(C=C2)CN3CCOCC3)C=C1)(C(F)F)O
InChI: InChI=1S/C25H27F2N3O5/c1-25(33,24(26)27)21(23(32)29-34)28-22(31)20-10-8-18(9-11-20)3-2-17-4-6-19(7-5-17)16-30-12-14-35-15-13-30/h4-11,21,24,33-34H,12-16H2,1H3,(H,28,31)(H,29,32)/t21?,25-/m0/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/mbio.00674-17

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