Compound ID | 2956

Update compound information

WCK-5153

Synonym(s): WCK5153

Class: Cell wall synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. PBP2 inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa
Description: Synthetic compound; has a bicyclo-acyl hydrazide scaffold - developed to improve PBP2 binding than its beta-lactamase inhibitory activity; has intrinsic antibacterial activity
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 377.38
Iso. SMILES: C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)O)C(=O)NNC(=O)[C@H]3CCNC3
InChI Key: NAURQUDBIPQVFZ-YIZRAAEISA-N
Can. SMILES: C1C[C@@H](C(=O)NNC(=O)[C@H]2CCNC2)N3C[C@@H]1N(C3=O)OS(=O)(=O)O
InChI: InChI=1S/C12H19N5O7S/c18-10(7-3-4-13-5-7)14-15-11(19)9-2-1-8-6-16(9)12(20)17(8)24-25(21,22)23/h7-9,13H,1-6H2,(H,14,18)(H,15,19)(H,21,22,23)/t7-,8+,9-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/133080588
Citation: https://journals.asm.org/doi/10.1128/aac.02529-16

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