Compound ID | 296

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J-114,871

Class: Beta-lactam (carbapenem)

Spectrum of activity: Gram-positive
Details of activity: Similar activity against P. aeruginosa as biapenem but improved MIC against MRSA (26 strains) compared to imipenem, meropenem and biapenem
Description: Adachi Y, Nagano R, Shibata K, et al. In vitro activities of J-111225, J-114870 and J-114871, novel carbapenems having potent activities against MRSA and Pseudomonas aeruginosa. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 246.
Institute where first reported: Banyu Pharmaceutical Co., Japan
Year first mentioned: 1998
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 474.58
Iso. SMILES: O=C1[C@@]([C@@H](C)O)([H])[C@]2([H])N1C(C(O)=O)=C(S[C@@H]3CN[C@@H](C4=CC=C([C@H](N)CC(N)=O)C=C4)C3)[C@@H]2C
InChI Key: DMOLXJPZOKHXIH-BQLQCADKSA-N
Can. SMILES: C[C@@H]1[C@]2([H])[C@@]([H])([C@@H](C)O)C(=O)N2C(=C1S[C@H]3C[C@H](C4=CC=C(C=C4)[C@@H](CC(=O)N)N)NC3)C(=O)O
InChI: InChI=1S/C23H30N4O5S/c1-10-19-18(11(2)28)22(30)27(19)20(23(31)32)21(10)33-14-7-16(26-9-14)13-5-3-12(4-6-13)15(24)8-17(25)29/h3-6,10-11,14-16,18-19,26,28H,7-9,24H2,1-2H3,(H2,25,29)(H,31,32)/t10-,11-,14+,15-,16-,18-,19-/m1/s1
External links:
Citations:
  • https://reader.elsevier.com/reader/sd/pii/S0960894X99006563?token=83932041AE27DE0A92F0B3CEBB8E4C1791D4115D6527FF8A2A5515C1ECA1B1AA61428D0E20CC96D53BC61BDE44F4FA100
  • https://www.sciencedirect.com/science/article/pii/S0968089600001255?via%3Dihub

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