Compound ID | 2960

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Blasticidin P10

Class: Nucleoside analogue

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae; protein synthesis inhibitor
Description: Natural product from marine sponge Theonella swinhoei; a blasticidin S analogue; cytotoxic to human lung fibroblasts at 5.9 ug/ml (selectivity index low); a peptidylnucleoside
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 421.45
Iso. SMILES: NC(N(C)CC[C@H](N)CC(N[C@H]1C=C[C@H](N2C=CC(N)=NC2=O)O[C@@H]1C(N)=O)=O)=N
InChI Key: ABWQJHQBCNRNIY-ZNIXKSQXSA-N
Can. SMILES: CN(CC[C@@H](CC(=O)N[C@H]1C=C[C@H](N2C=CC(=NC2=O)N)O[C@@H]1C(=O)N)N)C(=N)N
InChI: InChI=1S/C17H27N9O4/c1-25(16(21)22)6-4-9(18)8-12(27)23-10-2-3-13(30-14(10)15(20)28)26-7-5-11(19)24-17(26)29/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H2,20,28)(H3,21,22)(H,23,27)(H2,19,24,29)/t9-,10-,13+,14-/m0/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.02635-16

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