Compound ID | 2961

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Blasticidin derivative 16

Class: Nucleoside analogue

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus
Description: Semisynthetic compound derived from the natural product blasticidin; selectivity index at 26 (MRC-5 [lung fibroblast] CC50 vs Staphylococcus aureus MIC); a peptidylnucleoside
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 449.51
Iso. SMILES: NC(N(C)CC[C@H](N)CC(N[C@H]1C=C[C@H](N2C=CC(N)=NC2=O)O[C@@H]1C(NCC)=O)=O)=N
InChI Key: MTFFCFLAXMIQOM-RKLWJJNISA-N
Can. SMILES: CCNC(=O)[C@@H]1[C@H](C=C[C@H](N2C=CC(=NC2=O)N)O1)NC(=O)C[C@H](CCN(C)C(=N)N)N
InChI: InChI=1S/C19H31N9O4/c1-3-24-17(30)16-12(25-14(29)10-11(20)6-8-27(2)18(22)23)4-5-15(32-16)28-9-7-13(21)26-19(28)31/h4-5,7,9,11-12,15-16H,3,6,8,10,20H2,1-2H3,(H3,22,23)(H,24,30)(H,25,29)(H2,21,26,31)/t11-,12-,15+,16-/m0/s1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acsmedchemlett.3c00527

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