Compound ID | 2963

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REDX06213 

Class: DNA synthesis inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Acinetobacter baumannii, Clostridium difficile, Enterobacter cloacae, Enterococcus faecium, Enterococcus faecalis, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae; bacterial topoisomerase inhibitor
Description: Synthetic compound; cytotoxicity (IC50) towards mammalian cell line HepG2 at 29.6 ug/ml vs MIC at 8-0.12 ug/ml
Institute where first reported: Redx Pharma, Alderley Park, Cheshire, United Kingdom
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 504.54
Iso. SMILES: COC1=CC=C2C(N(CCN3CCC(NCC4=NC=5NC(COC5C=C4)=O)CC3)C(C6=NOC=C62)=O)=C1
InChI Key: MUUCSRSQPIPOCX-UHFFFAOYSA-N
Can. SMILES: COC1=CC2=C(C=C1)C3=CON=C3C(=O)N2CCN4CCC(CC4)NCC5=CC=C6C(=N5)NC(=O)CO6
InChI: InChI=1S/C26H28N6O5/c1-35-18-3-4-19-20-14-37-30-24(20)26(34)32(21(19)12-18)11-10-31-8-6-16(7-9-31)27-13-17-2-5-22-25(28-17)29-23(33)15-36-22/h2-5,12,14,16,27H,6-11,13,15H2,1H3,(H,28,29,33)
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.02100-16

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