Compound ID | 2964

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REDX07623

Class: DNA synthesis inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Acinetobacter baumannii, Clostridium difficile, Enterobacter cloacae, Enterococcus faecium, Enterococcus faecalis, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae, Bacillus anthracis, Francisella tularensis, and Yersinia pestis; bacterial topoisomerase inhibitor
Description: Synthetic compound; cytotoxicity (IC50) towards mammalian cell line HepG2 at 38 ug/ml vs MIC at 4-0.12 ug/ml
Institute where first reported: Redx Pharma, Alderley Park, Cheshire, United Kingdom
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 510.49
Iso. SMILES: FC1=CC=C2C(N(CCN3CCC(NCC4=NC=5NC(COC5C=C4F)=O)CC3)C(C6=NOC=C62)=O)=C1
InChI Key: WHPBMCINENAEFN-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1F)N(CCN3CCC(CC3)NCC4=C(C=C5C(=N4)NC(=O)CO5)F)C(=O)C6=NOC=C26
InChI: InChI=1S/C25H24F2N6O4/c26-14-1-2-16-17-12-37-31-23(17)25(35)33(20(16)9-14)8-7-32-5-3-15(4-6-32)28-11-19-18(27)10-21-24(29-19)30-22(34)13-36-21/h1-2,9-10,12,15,28H,3-8,11,13H2,(H,29,30,34)
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.02100-16

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