Compound ID | 2965

Update compound information

Toremifene 

Class: Membrane-active agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against oral infections caused by Porphyromonas gingivalis and Streptococcus mutans; likely disrupts integrity of cytoplasmic membrane
Description: Synthetic compound; a repurposed FDA-approved drug for breast cancer treatment
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 405.96
Iso. SMILES: CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\C2=CC=CC=C2)/C3=CC=CC=C3
InChI Key: XFCLJVABOIYOMF-QPLCGJKRSA-N
Can. SMILES: CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\C2=CC=CC=C2)/C3=CC=CC=C3
InChI: InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3005573
Citation: https://journals.asm.org/doi/10.1128/aac.01846-16

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