Compound ID | 2967

Update compound information

RBx 11760

Synonym(s): RBx11760

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against vancomycin-intermediate and -susceptible Staphylococcus aureus, Staphylococcus epidermidis, linezolid-resistant Staphylococcus aureus, vancomycin-resistant and -susceptible Enterococcus, linezolid-resistant Enterococcus, Streptococcus pneumoniae, and Clostridium difficile
Propensity to select resistant mutants: Yes, low at <3x10^-10 at 4xMIC for methicillin-resistant Staphylococcus aureus
Description: Synthetic compound; shows good bioavailability and low plasma clearance in mouse and rat
Institute where first reported: Department of Microbiology, Daiichi Sankyo India Pharma Private Limited, Gurgaon, Haryana, India;
Year first mentioned: 2016
Development status: Experimental
Chemical structure(s):
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Molecular weight: 397.36
Iso. SMILES: FC1=C(C=CC(N2C[C@H](CNC(C)=O)OC2=O)=C1)C3=CN=C(N=C3)N4N=CN=C4
InChI Key: UONUBOCPQDIAGF-AWEZNQCLSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC(=C(C=C2)C3=CN=C(N=C3)N4C=NC=N4)F)C(=O)O1
InChI: InChI=1S/C18H16FN7O3/c1-11(27)21-7-14-8-25(18(28)29-14)13-2-3-15(16(19)4-13)12-5-22-17(23-6-12)26-10-20-9-24-26/h2-6,9-10,14H,7-8H2,1H3,(H,21,27)/t14-/m0/s1
External links:
Citations:
  • https://academic.oup.com/jac/article/66/5/1087/781847?login=true
  • https://journals.asm.org/doi/10.1128/aac.00453-16

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