Compound ID | 297

Update compound information

J-114,870

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus
Description: Carbapenem type; improved MIC against MRSA (26 strains) compared to imipenem, meropenem and biapenem; Adachi Y, Nagano R, Shibata K, et al. In vitro activities of J-111225, J-114870 and J-114871, novel carbapenems having potent activities against MRSA and Pseudomonas aeruginosa. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 246.
Institute where first reported: Banyu Pharmaceutical Co., Japan
Year first mentioned: 1998
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 511.04
Iso. SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@@H](NC3)C4=CC=C(C=C4)[C@H](CC(=O)N)N)C(=O)O)[C@@H](C)O.Cl
InChI Key: IMBIQKQIKUQAQW-VNXSVTFKSA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]3C[C@H](C4=CC=C(C=C4)[C@H](CC(=O)N)N)NC3)C(=O)O.Cl
InChI: InChI=1S/C23H30N4O5S.ClH/c1-10-19-18(11(2)28)22(30)27(19)20(23(31)32)21(10)33-14-7-16(26-9-14)13-5-3-12(4-6-13)15(24)8-17(25)29;/h3-6,10-11,14-16,18-19,26,28H,7-9,24H2,1-2H3,(H2,25,29)(H,31,32);1H/t10-,11-,14+,15+,16-,18-,19-;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6918433
Citation: https://journals.asm.org/doi/10.1128/aac.44.3.489-495.2000

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.