Compound ID | 2970

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Campynexin A

Synonym(s): CCG-84443

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Campylobacter jejuni and Campylobacter coli
Description: Synthetic compound from small molecule collection of University of Michigan Center for Chemical Genomics (UM-CCG); shows no cytotoxicity towards human intestinal epithelial cells (Caco-2) at 100 uM (highest tested); reduces Campylobacter jejuni load in gastrointestinal tract of chicken to 1-log after treatment
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
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Molecular weight: 309.3
Iso. SMILES: CC1=NC2=NC(=NN2C(=C1)NC3=CC(=CC=C3)F)C4=CC=CO4
InChI Key: WGJHBURMACHFKM-UHFFFAOYSA-N
Can. SMILES: CC1=NC2=NC(=NN2C(=C1)NC3=CC(=CC=C3)F)C4=CC=CO4
InChI: InChI=1S/C16H12FN5O/c1-10-8-14(19-12-5-2-4-11(17)9-12)22-16(18-10)20-15(21-22)13-6-3-7-23-13/h2-9,19H,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/16028107
Citation: https://journals.asm.org/doi/10.1128/aac.04926-14

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