Compound ID | 2974

Update compound information

Campynexin E

Synonym(s): CCG-198215

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Campylobacter jejuni and Campylobacter coli
Description: Synthetic compound from small molecule collection of University of Michigan Center for Chemical Genomics (UM-CCG); shows no cytotoxicity towards human intestinal epithelial cells (Caco-2) at 100 uM (highest tested); reduces Campylobacter jejuni load in gastrointestinal tract of chicken to 1-log after treatment
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
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Molecular weight: 296.3
Iso. SMILES: CC1=C(C2=CC=CC=C2N1)C3(C4=C(C=CC(=C4)F)NC3=O)O
InChI Key: VHJWBVYFCNKSIT-UHFFFAOYSA-N
Can. SMILES: CC1=C(C2=C(C=CC=C2)N1)C3(C4=CC(=CC=C4NC3=O)F)O
InChI: InChI=1S/C17H13FN2O2/c1-9-15(11-4-2-3-5-13(11)19-9)17(22)12-8-10(18)6-7-14(12)20-16(17)21/h2-8,19,22H,1H3,(H,20,21)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/24805589
Citation: https://journals.asm.org/doi/10.1128/aac.04926-14

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