Compound ID | 2975
T9W
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-negative |
| Details of activity: | Active against Pseudomonas aeruginosa (including strains resistant to gentamicin, ceftazidime, and ciprofloxacin); membrane-active agent (binds to lipopolysaccharide to disrupt and depolarize cell membrane) |
| Description: | Synthetic compound; an 𝛼-helical antimicrobial peptide; shows synergistic activity effect with gentamicin and ciprofloxacin; cytotoxicity (10% viability reduction) towards macrophage cells at 290 ug/ml vs MIC at 2-4 ug/ml |
| Year first mentioned: | 2015 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.04830-14 |
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