Compound ID | 2977
Pyridineimidazole compound 2
Class: Small molecule antibacterial agent
| Spectrum of activity: | Gram-negative |
| Details of activity: | Active against Haemophilus influenzae and Escherichia coli; localization of lipoprotein (Lol) system inhibitor |
| Propensity to select resistant mutants: | Yes, high level at 10^-6 |
| Description: | Synthetic compound (pyridineimidazole scaffold); an analogue of pyridineimidazole compound 1 with ortho-methyl substitution off the pyridine; has low solubility and high protein binding in mammalian systems |
| Year first mentioned: | 2015 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/jb.02352-14 |
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