Compound ID | 2984
RattusinĀ
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against methicillin-resistant and -susceptible Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, Salmonella Typhimurium, and Klebsiella pneumoniae |
| Description: | Natural product from Bacillus cereus; an š¼-defensin; shows no cytotoxicity towards human Caco-2 cells at 365 ug/ml (highest tested) vs MIC at 2-8 ug/ml; retains antibacterial activity even in the presence of salts (i.e. NaCl or Mg2+) in contrast to other defensins |
| Year first mentioned: | 2013 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.02237-12 |
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