Compound ID | 2988

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NVC-422 (Aganocide®, Auriclosene)

Synonym(s): N,N-dichloro-2,2-dimethyltaurine

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pyogenes, vancomycin-resistant Enterococcus faecium, Staphylococcus epidermidis, Escherichia coli, Enterobacter aerogenes, Acinetobacter baumannii, Klebsiella pneumoniae, Proteus mirabilis, Haemophilus influenzae, Pseudomonas aeruginosa, and Serratia marcescens
Description: Synthetic compound; active and well tolerated when administered as topical gel treatment for impetigo in children
Institute where first reported: NovaBay Pharmaceuticals, Inc.
Year first mentioned: 2011
Highest development stage: Phase 2 (NCT01367314; NCT00781339; NCT01532336; NCT01877694; NCT01243125)
Development status: Active
Reason dropped: No results posted after clinical trial completion
Chemical structure(s):
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Molecular weight: 222.09
Iso. SMILES: CC(C)(CS(=O)(=O)O)N(Cl)Cl
InChI Key: QYNRGGHZWCUZLK-UHFFFAOYSA-N
Can. SMILES: CC(C)(CS(=O)(=O)O)N(Cl)Cl
InChI: InChI=1S/C4H9Cl2NO3S/c1-4(2,7(5)6)3-11(8,9)10/h3H2,1-2H3,(H,8,9,10)
External links:
Guide to Pharmacology: auriclosene
Citations:
  • https://journals.asm.org/doi/10.1128/aac.01945-12
  • https://journals.asm.org/doi/10.1128/aac.00158-11
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160610/

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