NVC-422 (Aganocide®, Auriclosene)

Synonym(s): N,N-dichloro-2,2-dimethyltaurine

Class: Antivirulence agent

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against Staphylococcus aureus, Streptococcus pyogenes, vancomycin-resistant Enterococcus faecium, Staphylococcus epidermidis, Escherichia coli, Enterobacter aerogenes, Acinetobacter baumannii, Klebsiella pneumoniae, Proteus mirabilis, Haemophilus influenzae, Pseudomonas aeruginosa, and Serratia marcescens
Description:	Synthetic compound; active and well tolerated when administered as topical gel treatment for impetigo in children
Institute where first reported:	NovaBay Pharmaceuticals, Inc.
Year first mentioned:	2011
Highest developmental phase:	Phase 2 (NCT01367314; NCT00781339; NCT01532336; NCT01877694; NCT01243125)
Development status:	Unknown
Reason Dropped:	No results posted after clinical trial completion

Chemical structure(s):
Canonical SMILES:	CC(C)(CS(=O)(=O)O)N(Cl)Cl
Isomeric SMILES:	CC(C)(CS(=O)(=O)O)N(Cl)Cl
InChI:	InChI=1S/C4H9Cl2NO3S/c1-4(2,7(5)6)3-11(8,9)10/h3H2,1-2H3,(H,8,9,10)
InChI Key:	QYNRGGHZWCUZLK-UHFFFAOYSA-N

External links:
Guide to Pharmacology:	auriclosene
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160610/
Citations:	https://journals.asm.org/doi/10.1128/aac.01945-12 https://journals.asm.org/doi/10.1128/aac.00158-11