Compound ID | 2992
Aminododecanoyl-lysyl-[aminodecanoyl-lysyl]5 (α12-5α10)
Synonym(s): Oligo-Acyl-Lysyl Hexamer (OAK)
Class: Antimicrobial peptide
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent. Disrupts integrity of cell membrane and also binds to lipoteichoic acid |
| Target Pathogen: | Active against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella enterica serovar Typhimurium, Salmonella enterica, Staphylococcus epidermidis, and Streptococcus pyogenes |
| Description: | Synthetic compound; no cytotoxicity to human foreskin fibroblasts and haemolytic activity at 100 ug/ml (highest tested) vs MIC at ~3-12 ug/ml); shows synergistic effect with erythromycin |
| Year first mentioned: | 2012 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.00511-12 |
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