Compound ID | 2997

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Loureirin A

Class: Natural product antibiotic

Spectrum of activity: Gram-negative
Details of activity: Active against Helicobacter pylori; induces generation of reactive oxygen species leading to bacterial cell death
Description: Natural product from the resin of Dracaena plant; a dihydrochalcone; a flavonoid; shows synergistic effect with omeprazole and other antibiotics (levafloxacin, metronidazole, tetracycline, and furazolidone); shows additive effect with omeprazole and other antibiotics (levafloxacin, metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone); high therapeutic efficacy in mice infection when administered in combination with omeprazole
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 286.32
Iso. SMILES: COC1=CC(=C(C=C1)CCC(=O)C2=CC=C(C=C2)O)OC
InChI Key: RSAIVLRELNGZEY-UHFFFAOYSA-N
Can. SMILES: COC1=CC=C(CCC(=O)C2=CC=C(C=C2)O)C(=C1)OC
InChI: InChI=1S/C17H18O4/c1-20-15-9-5-13(17(11-15)21-2)6-10-16(19)12-3-7-14(18)8-4-12/h3-5,7-9,11,18H,6,10H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5319081
Guide to Pharmacology: loureirin A
Citation: https://journals.asm.org/doi/10.1128/aac.00314-24?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

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