Loureirin A

Class: Natural product antibiotic (flavonoid)

Spectrum of activity:	Gram-negative
Details of activity:	Active against Helicobacter pylori; induces generation of reactive oxygen species leading to bacterial cell death
Description:	Natural product from the resin of Dracaena plant; a dihydrochalcone; shows synergistic effect with omeprazole and other antibiotics (levafloxacin, metronidazole, tetracycline, and furazolidone); shows additive effect with omeprazole and other antibiotics (levafloxacin, metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone); high therapeutic efficacy in mice infection when administered in combination with omeprazole
Year first mentioned:	2024
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	COC1=CC=C(CCC(=O)C2=CC=C(C=C2)O)C(=C1)OC
Isomeric SMILES:	COC1=CC(=C(C=C1)CCC(=O)C2=CC=C(C=C2)O)OC
InChI:	InChI=1S/C17H18O4/c1-20-15-9-5-13(17(11-15)21-2)6-10-16(19)12-3-7-14(18)8-4-12/h3-5,7-9,11,18H,6,10H2,1-2H3
InChI Key:	RSAIVLRELNGZEY-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5319081

External links:
Guide to Pharmacology:	loureirin A
Main Source:	https://journals.asm.org/doi/10.1128/aac.00314-24?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed