Compound ID | 3006

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eAmSPC 2694

Class: Aminoglycoside

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Mycobacterium abscessus, Mycobacterium tuberculosis, and Mycobacterium avium
Description: Semisynthetic compound; derived from spectinomycin (N-ethylene linked aminomethyl spectinomycin); shows synergistic effect with clarithromycin, linezolid, bedaquiline, and clofazimine
Institute where first reported: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 475.58
Iso. SMILES: CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3([C@](O)(CNCCC4CCOCC4)C[C@@H](C)O[C@H]3O[C@@H]2[C@H]1O)O
InChI Key: LKCDGONKFJKONL-WUYRLSBSSA-N
Can. SMILES: C[C@@H]1C[C@@](CNCCC2CCOCC2)([C@]3([C@@H](O1)O[C@@H]4[C@H]([C@@H]([C@@H]([C@@H]([C@H]4O3)NC)O)NC)O)O)O
InChI: InChI=1S/C22H41N3O8/c1-12-10-21(28,11-25-7-4-13-5-8-30-9-6-13)22(29)20(31-12)32-19-17(27)14(23-2)16(26)15(24-3)18(19)33-22/h12-20,23-29H,4-11H2,1-3H3/t12-,14-,15+,16+,17+,18-,19-,20+,21-,22-/m1/s1
External links:
Citation: https://www.pnas.org/doi/10.1073/pnas.2314101120

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