Compound ID | 3007

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Argyrin B 

Class: Antimicrobial peptide

Spectrum of activity: Gram-negative
Details of activity: Active against Pseudomonas aeruginosa; protein synthesis inhibitor (binds to elongation factor G [EF-G])
Description: Natural product from Actinoplanes sp. (also produced by myxobacteria Archangium gephyra and Cystobacter sp. SBCb004); total chemical synthesis reported; octapeptide scaffold
Institute where first reported: Marion Merrell Dow Research Institute, Lepetit Research Center
Year first mentioned: 1996
Development status: Experimental
Chemical structure(s):
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Molecular weight: 838.93
Iso. SMILES: CC[C@@H]1C(=O)NC(=C)C(=O)N(CC(=O)N[C@@H](C2=NC(=CS2)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CC3=CNC4=C3C(=CC=C4)OC)CC5=CNC6=CC=CC=C65)C)C
InChI Key: OVJDNZFLEREPKG-VPMCBBNJSA-N
Can. SMILES: CC[C@@H]1C(=O)NC(=C)C(=O)N(C)CC(=O)N[C@H](C)C2=NC(=CS2)C(=O)N[C@@H](CC3=CNC4=C3C=CC=C4)C(=O)N[C@@H](CC5=CNC6=CC=CC(=C56)OC)C(=O)NCC(=O)N1
InChI: InChI=1S/C41H46N10O8S/c1-6-26-37(55)46-22(3)41(58)51(4)19-34(53)45-21(2)40-50-31(20-60-40)39(57)49-30(14-23-16-42-27-11-8-7-10-25(23)27)38(56)48-29(36(54)44-18-33(52)47-26)15-24-17-43-28-12-9-13-32(59-5)35(24)28/h7-13,16-17,20-21,26,29-30,42-43H,3,6,14-15,18-19H2,1-2,4-5H3,(H,44,54)(H,45,53)(H,46,55)(H,47,52)(H,48,56)(H,49,57)/t21-,26-,29+,30+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9940787
Citations:
  • https://www.pnas.org/doi/10.1073/pnas.2114214119
  • https://www.jstage.jst.go.jp/article/antibiotics1968/49/2/49_2_145/_article

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