Compound ID | 3008
NDM1i-1F and NDM1i-1G
Class: Beta-lactamase inhibitor
| Details of activity: | Binds to NDM-1 at the same site as D-captopril (a known small molecule weak competitive inhibitor of NDM-1); NDM inhibitor |
| Description: | Synthetic compound; a peptide macrocyle; other derivatives reported (i.e. NDM1i-2A to NDM1i-2K) |
| Institute where first reported: | Center for Computational Biology, Flatiron Institute, New York USA; Institute for Protein Design, Department of Biochemistry, Molecular Engineering and Sciences, University of Washington, Seattle, USA |
| Year first mentioned: | 2021 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.2012800118 |
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