Compound ID | 3009

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Burkfloxacin

Synonym(s): BFX

Class: Fluoroquinolone

Spectrum of activity: Gram-negative
Details of activity: Active against intracellular Burkholderia pseudomallei, Burkholderia mallei, Burkholderia thailandensis, Escherichia coli, and Pseudomonas aeruginosa; bacterial topoisomerase inhibitor (DNA gyrase inhibitor)
Description: Synthetic compound identified from screening small molecules; efficacious and superior to ceftazidime in preclinical model of fulminant melioidosis
Institute where first reported: Kyorin Pharmaceutical Co., Ltd., Japan
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 320.32
Iso. SMILES: OC(C1=CN(CC)C2=CC(N3CCOCC3)=C(F)C=C2C1=O)=O
InChI Key: CWGUZPQPISQBPV-UHFFFAOYSA-N
Can. SMILES: CCN1C=C(C(=O)C2=C1C=C(C(=C2)F)N3CCOCC3)C(=O)O
InChI: InChI=1S/C16H17FN2O4/c1-2-18-9-11(16(21)22)15(20)10-7-12(17)14(8-13(10)18)19-3-5-23-6-4-19/h7-9H,2-6H2,1H3,(H,21,22)
External links:
Citations:
  • https://pubs.acs.org/doi/abs/10.1021/jm00186a014
  • https://www.pnas.org/doi/10.1073/pnas.1906388116

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