Compound ID | 3010

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Flucytosine (prodrug)

Synonym(s): 5-FC

Class: Antivirulence agent

Spectrum of activity: Gram-negative
Details of activity: Active against intracellular Burkholderia pseudomallei and Burkholderia thailandensis; targets T6SS-5
Description: Synthetic compound; an FDA approved antifungal drug; inhibits cell to cell spread of Burkholderia sp.; does not have intrinsic antibacterial activity as it is a prodrug that requires conversion to 5-fluorouracil and fluorouridine monophosphate for inhibitory activity; efficacious and superior to ceftazidime in preclinical model of fulminant melioidosis
Year first mentioned: 2019
Development status: Experimental
Chemical structure(s):
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Molecular weight: 129.09
Iso. SMILES: C1=NC(=O)NC(=C1F)N
InChI Key: XRECTZIEBJDKEO-UHFFFAOYSA-N
Can. SMILES: C1=NC(=O)NC(=C1F)N
InChI: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3366
Citation: https://www.pnas.org/doi/10.1073/pnas.1906388116

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