Compound ID | 3023

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Althiomycin

Synonym(s): Matamycin

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Streptococcus pneumoniae, Staphylococcus aureus, Bacillus anthracis, Escherichia coli, Shigella dysenteriae, Salmonella typhosa, and Salmonella paratyphi; protein synthesis inhibitor (likely binds to 50S ribosomal subunit and blocks peptide bond formation)
Description: Natural product from Streptomyces althioticus (previously identified as strain No. 245-Z 2); a thiazole
Year first mentioned: 1957
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES:
InChI Key:
Can. SMILES: COC1=CC(=O)N(C1)C(=O)C2CSC(=N2)C(CO)NC(=O)C3=CSC(=N3)C=NO
InChI:
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/73420
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/23/6/23_6_271/_article
  • https://www.jstage.jst.go.jp/article/antibioticsa/10/5/10_195/_article/-char/en

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