Compound ID | 3040

Update compound information

Gougerotin

Synonym(s): Aspiculamycin  |  Antibiotic 21544

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Escherichia coli (only Gram-negative it is active against), Mycobacterium avium and Mycobacterium tuberculosis; protein synthesis inhibitor
Description: Natural product from Streptomyces gougerotii; has a pyrimidine scaffold; shows delayed toxicity in mice
Institute where first reported: Research Laboratories, Takeda Chemical Industries, Ltd., Osaka
Year first mentioned: 1962
Development status: Experimental
Chemical structure(s):
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Molecular weight: 443.41
Iso. SMILES: CNCC(=O)N[C@H](CO)C(=O)N[C@H]1[C@@H]([C@H]([C@@H](O[C@@H]1C(=O)N)N2C=CC(=NC2=O)N)O)O
InChI Key: AMNAZJFEONUVTD-QJHHURCWSA-N
Can. SMILES: CNCC(=O)NC(CO)C(=O)NC1C(C(C(OC1C(=O)N)N2C=CC(=NC2=O)N)O)O
InChI:
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11226719
Citation: https://www.jstage.jst.go.jp/article/antibioticsa/15/2/15_93/_article/-char/en

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