Compound ID | 3050

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Danomycin

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Corynebacterium xerosis, Bacillus anthracis, and Streptococcus pneumoniae
Propensity to select resistant mutants: Yes, at 10^-5 mutation frequency at 35 ug/ml
Description: Natural product from Streptomyces albaduncus; shows curative dose (CD50) comparable to penicillin G in treating Staphylococcus aureus infection in mice; a sideromycin
Institute where first reported: Bristol-Banyu Research Institute, Ltd.
Year first mentioned: 1964
Highest developmental phase: Preclinical
Development status: Experimental
External links:
Citations:
  • https://www.jstage.jst.go.jp/article/antibioticsa/17/2/17_48/_article/-char/en
  • https://www.jstage.jst.go.jp/article/antibioticsa/17/2/17_39/_article/-char/en

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