Compound ID | 3052

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Lancovutide

Synonym(s): Leucopeptin  |  Duramycin

Class: Antimicrobial peptide

Details of activity: Active against Mycobacterium smegmatis; potentially membrane-active agent
Description: Natural product from Streptomyces hachijoensis var. takahagiensis; in Phase 2 clinical trial (NCT00671736) as treatment in cystic fibrosis but not as antibiotic
Institute where first reported: Research Laboratories, Meiji Seika Kaisha, Ltd.
Year first mentioned: 1964
Development status: Experimental
Chemical structure(s):
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Molecular weight: 2013.29
Iso. SMILES: C[C@H]1[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]3CSC[C@@H]4C(=O)N[C@@H](CS1)C(=O)N[C@@H](CNCCCC[C@H](NC(=O)[C@@H]([C@@H](SC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CCC(=O)N)CCCCN)N)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC3=O)[C@H](C(=O)O)O)CC(=O)N)C(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N2)CC6=CC=CC=C6)CC7=CC=CC=C7)C(C)C)CC8=CC=CC=C8
InChI Key: SFWLDKQAUHFCBS-AOEYGKNYSA-N
Can. SMILES: CC1C2C(=O)NC(C(=O)NC(C(=O)NC3CSCC4C(=O)NC(CS1)C(=O)NC(CNCCCCC(NC(=O)C(C(SCC(C(=O)NC(C(=O)NC(C(=O)N4)CCC(=O)N)CCCCN)N)C)NC(=O)C(NC(=O)CNC(=O)C(NC3=O)C(C(=O)O)O)CC(=O)N)C(=O)O)C(=O)NC(C(=O)NCC(=O)N5CCCC5C(=O)NC(C(=O)N2)CC6=CC=CC=C6)CC7=CC=CC=C7)C(C)C)CC8=CC=CC=C8
InChI:
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/139593411
Citation: https://www.jstage.jst.go.jp/article/antibioticsa/17/6/17_262/_article/-char/en

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