Compound ID | 3053

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Proceomycin

Synonym(s): Paulomycin  |  U-43,120

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against multidrug-resistant Staphylococcus aureus, Bacillus athracis, Corynebacterium xerosis, Lactobacillus casei, Lactobacillus acidophilus, Streptococcus pneumoniae, Enterococcus faecalis, and Haemophilus influenzae (only Gram-negative it is active against)
Description: Natural product from Streptomyces albolongus; a glycosylated antibiotic; shows in vivo activity against staphylococcal infection in mice but severe local tissue toxicity in animals had been reported; chemically unstable
Institute where first reported: Bristol-Banyu Research Institute, Ltd.
Year first mentioned: 1964
Development status: Experimental
Chemical structure(s):
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Molecular weight: 658.63
Iso. SMILES: C/C=C(/C(=O)O[C@@H]1[C@H](OC([C@@H]([C@@H]1O[C@@H]2C[C@H]([C@H]([C@H](O2)C)O)OC)O)C3(CC(=O)C(=N)C(=C3O)C(=O)O)O)COC(=O)C)\N=C=S
InChI Key: JDQIPVJZDQWDSX-RBBXPHQJSA-N
Can. SMILES: CC=C(C(=O)OC1C(OC(C(C1OC2CC(C(C(O2)C)O)OC)O)C3(CC(=O)C(=N)C(=C3O)C(=O)O)O)COC(=O)C)N=C=S
InChI:
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135612718
Citation: https://www.jstage.jst.go.jp/article/antibioticsa/17/6/17_223/_article/-char/en

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