Compound ID | 3059

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Lolamicin

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae, and Enterobacter cloacae, but not active against Gram-positives; targets the lipoprotein transport system
Description: Synthetic compound; derived by combining pyridinepyrazole and pyridineimidazole and further modified to improve accumulation in Gram-negative; shows no activity against Gram-negative gut commensals; reduces bacterial burden by 3-log when administered orally in mice infected with colistin-resistant Escherichia coli; no activity against
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 380.44
Iso. SMILES: CC1=NC(=CC(=C1)C2=C(C3=CC(=CC=C3)OCC4=CC(=CC=C4)C#N)NN=C2)C
InChI Key: CIXIQLLJOWEAKU-UHFFFAOYSA-N
Can. SMILES: CC1=NC(=CC(=C1)C2=C(C3=CC(=CC=C3)OCC4=CC(=CC=C4)C#N)NN=C2)C
InChI: InChI=1S/C24H20N4O/c1-16-9-21(10-17(2)27-16)23-14-26-28-24(23)20-7-4-8-22(12-20)29-15-19-6-3-5-18(11-19)13-25/h3-12,14H,15H2,1-2H3,(H,26,28)
External links:
Guide to Pharmacology: lolamicin
Citation: https://www.nature.com/articles/s41586-024-07502-0

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