Compound ID | 306

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Guanacastepene

Synonym(s): CR115

Class: Membrane-active agent

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent
Target Pathogen: Active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus
Description: Natural product from plant fungal endophyte; Singh MP, Janso JE, Luckman SW, et al. Biological activity of CR115, a novel diterpenoid antibiotic isolated from an unidentified fungus. 38th-Intersci-Conf-Antimicrobial-Agents-Chemother 1998; 280.
Institute where first reported: Wyeth, USA
Year first mentioned: 1998
Development status: Experimental
Chemical structure(s):
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Molecular weight: 374.47
Iso. SMILES: CC(C)[C@H]1[C@H](C(=O)C2=CC3=C([C@H](CC[C@]3(CC[C@]12C)C)O)C=O)OC(=O)C
InChI Key: KCPNSIPCHJTGHJ-MYHSIESUSA-N
Can. SMILES: CC(C)[C@H]1[C@H](C(=O)C2=CC3=C(C=O)[C@H](CC[C@@]3(C)CC[C@@]21C)O)OC(=O)C
InChI: InChI=1S/C22H30O5/c1-12(2)18-20(27-13(3)24)19(26)16-10-15-14(11-23)17(25)6-7-21(15,4)8-9-22(16,18)5/h10-12,17-18,20,25H,6-9H2,1-5H3/t17-,18-,20+,21-,22-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10384802
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/53/3/53_3_256/_pdf/-char/en

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