Compound ID | 3062
Coumermycin A2
Class: DNA synthesis inhibitor
| Agent Type: | Natural product; Small molecule; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | DNA synthesis inhibitor. Bacterial topoisomerase inhibitor (targets DNA gyrase B subunit) |
| Target Pathogen: | Active against Staphylococcus aureus, Corynebacterium xerosis, Bacillus anthracis, Escherichia coli, and Salmonella paratyphi A |
| Description: | Natural product from Streptomyces rishiriensis; coumarin scaffold |
| Institute where first reported: | Bristol-Banyu Research Institute, Ltd. |
| Year first mentioned: | 1965 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.jstage.jst.go.jp/article/antibioticsa/18/5/18_220/_article/-char/en |
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