Compound ID | 3067

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MC21-A (C58)

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus; potential FtsZ inhibitor
Description: Natural product from Pseudoalteromonas phenolica; polybrominated biphenyl scaffold; full chemical synthesis reported; shows haemolytic activity at 32x MIC; cytotoxicity towards human bronchial epithelial and dermal fibroblast cells at LD50 59.3 an 71.3 ug/ml respectively vs MIC at 2 ug/ml
Year first mentioned: 2003
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES:
InChI Key:
Can. SMILES: C1=C(C=C(C(=C1C2=C(C(=CC(=C2)Br)Br)O)O)Br)Br
InChI:
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/30891
Citations:
  • https://journals.asm.org/doi/10.1128/spectrum.01515-22
  • https://journals.asm.org/doi/10.1128/aac.47.2.480-488.2003

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