Cervimycin C

Class: Natural product antibiotic (polyketide)

Spectrum of activity:	Gram-positive
Details of activity:	Active against Staphylococcus aureus; targets DNA gyrase (bacterial topoisomerase inhibitor)
Description:	Natural product from Streptomyces tendae
Year first mentioned:	2024
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC1C(CCC(O1)OC2CCC(OC2C)OC34C(CC5=CC6=C(C(=O)C=C(C6=O)OC)C(=C5C3=O)O)C(C(=O)C(=C4O)C(=O)N)OC7CCC(C(O7)C)OC8CCC(C(O8)C)OC9CCC(C(O9)C)OC1CCC(C(O1)C)OC(=O)C(C)(C)C(=O)O)O
Isomeric SMILES:	C[C@@H]1[C@H](CC[C@@H](O1)O[C@H]2CC[C@@H](O[C@@H]2C)O[C@]34[C@H](CC5=CC6=C(C(=O)C=C(C6=O)OC)C(=C5C3=O)O)[C@H](C(=O)C(=C4O)C(=O)N)O[C@H]7CC[C@@H]([C@H](O7)C)O[C@H]8CC[C@@H]([C@@H](O8)C)O[C@H]9CC[C@@H]([C@@H](O9)C)O[C@H]1CC[C@@H]([C@@H](O1)C)OC(=O)C(C)(C)C(=O)O)O
InChI:
InChI Key:	CYKZTBKVWQAQLU-KSQSWLAPSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/54687465

External links:
Guide to Pharmacology:	cervimycin C
Main Source:	https://journals.asm.org/doi/10.1128/msphere.00764-23