Compound ID | 3070
LEI-800
Class: Bacterial topoisomerase inhibitor
| Spectrum of activity: | Gram-negative |
| Details of activity: | Active against fluoroquinolone-resistant Escherichia coli and Klebsiella pneumoniae; binds to a hydrophobic pocket in the GyrA subunit |
| Description: | Synthetic compound modified from a hit in a screening small molecule library; an isoquinoline sulfonamide |
| Institute where first reported: | Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Guide to Pharmacology: | LEI-800 |
| Main Source: | https://www.nature.com/articles/s41557-024-01516-x |
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