Compound ID | 3089
Actinotiocin
Class: Antimicrobial peptide
| Agent Type: | Natural product; |
| Spectrum of activity: | Gram-positive & Antimycobacterial |
| Mechanism of action: | Unknown |
| Target Pathogen: | Active against Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus hemolyticus, Listeria monocytogenes, Mycoplasma sp., and Mycobacterium tuberculosis |
| Description: | Natural product from Actinomadura pusilla A-118 (S2-118); shows protective effect in intraperitoneal infection with Staphylococcus aureus (70% survival) and Streptococcus pneumoniae (100% survival) in mice when administered via intraperitoneal route (vs no effect when administered orally); sulfur-containing peptide |
| Institute where first reported: | Dainippon Pharmaceutical Co., Ltd. |
| Year first mentioned: | 1973 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.jstage.jst.go.jp/article/antibiotics1968/26/6/26_6_343/_article/-char/en |
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