Compound ID | 3115

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Antibiotic G-52

Synonym(s): 6'-N-methylsisomicin

Class: Aminoglycoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella sp. ; protein synthesis inhibitor; active against strains expressing acetyl transferase (AAC-6')
Description: Natural product from Micromonospora zionensis; rescues mice from infection with broad-spectrum pathogens but inferior to gentamicin; shows toxicity comparable to gentamicin
Institute where first reported: Microbiological Sciences, Schering Corporation, USA
Year first mentioned: 1976
Development status: Experimental
Chemical structure(s):
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Molecular weight: 461.55
Iso. SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(CC=C(O3)CNC)N)N)N)O
InChI Key: ARCVBMPERJRMKB-UHFFFAOYSA-N
Can. SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(CC=C(CNC)O3)N)N)N)O
InChI: InChI=1S/C20H39N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h4,10-19,24-28H,5-8,21-23H2,1-3H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/171087
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804068/#B39-molecules-24-03430
  • https://www.jstage.jst.go.jp/article/antibiotics1968/29/5/29_5_483/_article

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