Compound ID | 3119

Update compound information

Lenoremycin

Synonym(s): Ro 21-6150  |  Antibiotic A 130A

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus, Mycobacterium phlei, Streptococcus pyogenes, Streptococcus faecalis, Corynebacterium diphtheriae, Streptococcus pneumoniae, and Mycobacterium tuberculosis
Description: Natural product from Streptomyces hygroscopicus; a polyether ionophore
Institute where first reported: Chemical Research Department, Hoffmann-La Roche Inc.; Shionogi Research Laboratory, Shionogi & Co., Ltd.
Year first mentioned: 1975
Development status: Experimental
Chemical structure(s):
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Molecular weight: 851.12
Iso. SMILES: C[C@@H]1CC[C@@H](O[C@@]12[C@H](C[C@@H](O2)[C@@H]3[C@H](C[C@H]([C@@](O3)(CO)O)C)C)C)[C@@]4(CC[C@@]5(O4)[C@@H]([C@@H](C[C@H](O5)[C@@H](C)/C=C(\C)/C(=O)[C@H](C)C[C@H](C)C(=O)O)O[C@H]6CC[C@@H]([C@H](O6)C)OC)C)C
InChI Key: LQFPDTISEHAMNQ-JRSQRZRGSA-N
Can. SMILES: C[C@@H](/C=C(\C)/C(=O)[C@H](C)C[C@H](C)C(=O)O)[C@@H]1C[C@H]([C@@H](C)[C@]2(CC[C@@](C)([C@H]3CC[C@@H](C)[C@]4([C@@H](C)C[C@H]([C@@H]5[C@@H](C)C[C@@H](C)[C@@](CO)(O)O5)O4)O3)O2)O1)O[C@H]6CC[C@@H]([C@@H](C)O6)OC
InChI: InChI=1S/C47H78O13/c1-25(19-26(2)41(49)27(3)20-29(5)43(50)51)36-23-37(55-40-16-14-35(53-12)34(10)54-40)33(9)46(56-36)18-17-44(11,60-46)39-15-13-30(6)47(58-39)32(8)22-38(57-47)42-28(4)21-31(7)45(52,24-48)59-42/h19,25,27-40,42,48,52H,13-18,20-24H2,1-12H3,(H,50,51)/b26-19+/t25-,27+,28-,29-,30+,31+,32-,33+,34+,35-,36-,37+,38+,39+,40-,42-,44-,45-,46+,47+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6441669
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/29/1/29_1_21/_article/-char/en

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