Compound ID | 312
PGE-956 7567
Class: Cell-wall synthesis inhibitor (biarylamide)
| Spectrum of activity: | Gram-negative |
| Description: | 1. Beirman JC, Emig JE, Malllalieu NL, et al. In vivo antibacterial activity and pharmokinetics for a series of biarylamide compounds. 39th-ICAAC 1999;331. 2. Hershberger PM, Shrum GP, Wilson LJ, et al. Synthesis and biological properties of biarylamide antibacterial agents . 39th-ICAAC 1999;331. |
| Institute where first reported: | Procter and Gamble Pharmaceuticals, Ireland |
| Year first mentioned: | 1999 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| Reason Dropped: | Failed in protecting septicemia model in mice which is thought to be an issue with bioavailability and unfavourable PK (1) |
| External links: | |
| Citations: |
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