Compound ID | 3127

Update compound information

Dityromycin

Synonym(s): AM-2504

Class: Antimicrobial peptide

Agent Type: Natural product; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Targets small ribosomal subunit to inhibit translocation during protein synthesis
Target Pathogen: Active against Corynebacterium paurometabolum and Clostridium spp.
Description: Natural product from Streptomyces sp.
Year first mentioned: 1977
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1289.48
Iso. SMILES: C[C@@H]1[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N([C@H](C(=O)NC(=C(CO)C3CO3)C(=O)N4CCC[C@H]4C(=O)N[C@H]5C(C6=CC(=C(C=C6)OC)OC7=CC=C(C=C7)C=C(C(=O)O1)N(C(=O)[C@@H](N(C5=O)C)C(C)C)C)O)C(C)C)C)C8=CC=CC=C8)C(C)C)N(C)C
InChI Key: RSUZULAECJTHIX-RBZOKQBQSA-N
Can. SMILES: CC(C)[C@H]1C(=O)N[C@@H](C2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)N(C)[C@@H](C(C)C)C(=O)NC(=C(CO)C4CO4)C(=O)N5CCC[C@H]5C(=O)N[C@H]6C(C7=CC=C(C(=C7)OC8=CC=C(C=C8)C=C(C(=O)O[C@H](C)[C@@H](C(=O)N1)N(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C6=O)OC)O
InChI: InChI=1S/C67H88N10O16/c1-35(2)50-59(81)69-51(40-19-15-14-16-20-40)64(86)77-30-18-22-45(77)62(84)74(11)54(36(3)4)60(82)70-52(43(33-78)49-34-91-49)65(87)76-29-17-21-44(76)58(80)71-53-57(79)41-25-28-47(90-13)48(32-41)93-42-26-23-39(24-27-42)31-46(67(89)92-38(7)56(72(8)9)61(83)68-50)73(10)66(88)55(37(5)6)75(12)63(53)85/h14-16,19-20,23-28,31-32,35-38,44-45,49-51,53-57,78-79H,17-18,21-22,29-30,33-34H2,1-13H3,(H,68,83)(H,69,81)(H,70,82)(H,71,80)/t38-,44+,45+,49?,50+,51+,53+,54+,55+,56+,57?/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/139584733
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0040403900820900#:~:text=Dityromycin%20is%20a%20peptide%20antibiotic,showing%20activities%20against%20%2C%20%2C%20and%20.
  • https://www.jstage.jst.go.jp/article/bbb1961/41/9/41_9_1827/_article/-char/en

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