Compound ID | 3131
Sequanamycin A
Synonym(s): SEQ-503
Class: Macrolide
| Agent Type: | Natural product; Small molecule; Direct acting; |
| Spectrum of activity: | Antimycobacterial |
| Mechanism of action: | Protein synthesis inhibitor. Binds to the same site as erythromycin |
| Target Pathogen: | Active against Mycobacterium tuberculosis |
| Description: | Natural product from Allokutzneria albata; erythromycin-type; unstable in acidic medium suggesting it would likely undergo stomach degradation; metabolically unstable (67% metabolised within 20 minutes) in human liver microsomes |
| Year first mentioned: | 1969 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.cell.com/cell/pdf/S0092-8674(23)00102-2.pdf |
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