Compound ID | 3132

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QPX7831 (Prodrug of QPX7728)

Synonym(s): QPX-7831  |  QPX 7831  |  Compound 5-Na

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against class A and class C enzymes from Enterobacterales, and class B metalloenzymes (NDM-1) and class D enzymes from Acinetobacter spp.
Description: Synthetic compound; shows no intrinsic antibacterial activity
Institute where first reported: Qpex Biopharma, San Diego, California, United States
Year first mentioned: 2021
Highest developmental phase: Phase 1 (NCT04578873, NCT06157242, NCT06079775)
Development status: Active
Chemical structure(s):
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Molecular weight: 322.09
Iso. SMILES: B1([C@@H]2C[C@@H]2C3=C(O1)C(=C(C=C3)F)C(=O)OCOC(=O)C(C)C)O
InChI Key: FCXHIXHOQJYLTG-NXEZZACHSA-N
Can. SMILES: CC(C)C(=O)OCOC(=O)C1=C2C(=CC=C1F)[C@H]3C[C@H]3B(O)O2
InChI: InChI=1S/C15H16BFO6/c1-7(2)14(18)21-6-22-15(19)12-11(17)4-3-8-9-5-10(9)16(20)23-13(8)12/h3-4,7,9-10,20H,5-6H2,1-2H3/t9-,10-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/156858930
Guide to Pharmacology: xeruborbactam isoboxil
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01722

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