QPX7831 (Prodrug of QPX7728)

Synonym(s): QPX-7831  |  QPX 7831  |  Compound 5-Na

Class: Beta-lactamase inhibitor

Spectrum of activity:	Gram-negative
Details of activity:	Active against class A and class C enzymes from Enterobacterales, and class B metalloenzymes (NDM-1) and class D enzymes from Acinetobacter spp.
Description:	Synthetic compound; shows no intrinsic antibacterial activity
Institute where first reported:	Qpex Biopharma, San Diego, California, United States
Year first mentioned:	2021
Highest developmental phase:	Phase 1 (NCT04578873, NCT06157242, NCT06079775)
Development status:	Active

Chemical structure(s):
Canonical SMILES:	CC(C)C(=O)OCOC(=O)C1=C2C(=CC=C1F)[C@H]3C[C@H]3B(O)O2
Isomeric SMILES:	B1([C@@H]2C[C@@H]2C3=C(O1)C(=C(C=C3)F)C(=O)OCOC(=O)C(C)C)O
InChI:	InChI=1S/C15H16BFO6/c1-7(2)14(18)21-6-22-15(19)12-11(17)4-3-8-9-5-10(9)16(20)23-13(8)12/h3-4,7,9-10,20H,5-6H2,1-2H3/t9-,10-/m1/s1
InChI Key:	FCXHIXHOQJYLTG-NXEZZACHSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/156858930

External links:
Guide to Pharmacology:	xeruborbactam isoboxil
Main Source:	https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01722