Compound ID | 3144

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Permetin

Synonym(s): Permetin A  |  Permycin  |  NLF-II

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Escherichia coli, Salmonella typhimurium, Klebsiella sp., Pseudomonas aeruginosa, Staphylococcus aureus, and Clostridium sp.
Description: Natural product from Bacillus circulans
Institute where first reported: Central Research Laboratories, Ajinomoto Co. Inc.
Year first mentioned: 1979
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1101.38
Iso. SMILES: CCC(C)C1CC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O1)CO)CC(C)C)C(C)C)CCN)CC(C)C)CC2=CC=CC=C2)CCN)C(C)CC)CCN
InChI Key: NPQJTPHMCZYCNP-UHFFFAOYSA-N
Can. SMILES: CCC(C)C1CC(=O)NC(CCN)C(=O)NC(C(C)CC)C(=O)NC(CCN)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(CCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)O1
InChI: InChI=1S/C54H92N12O12/c1-11-32(9)42-27-43(68)58-35(18-21-55)47(70)66-45(33(10)12-2)53(76)60-36(19-22-56)46(69)62-40(26-34-16-14-13-15-17-34)51(74)61-38(24-29(3)4)49(72)59-37(20-23-57)48(71)65-44(31(7)8)52(75)63-39(25-30(5)6)50(73)64-41(28-67)54(77)78-42/h13-17,29-33,35-42,44-45,67H,11-12,18-28,55-57H2,1-10H3,(H,58,68)(H,59,72)(H,60,76)(H,61,74)(H,62,69)(H,63,75)(H,64,73)(H,65,71)(H,66,70)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/172928
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/32/2/32_2_121/_article/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/32/2/32_2_115/_article

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