Dactimycin

Synonym(s): SF-2052  |  Dactimicin

Class: Aminoglycoside

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against Staphylococcus aureus, Escherichia coli, Salmonella sp., Klebsiella pneumoniae, and Mycobacterium smegmatis
Description:	Natural product from Dactylosporangium matsuzaklease
Institute where first reported:	Central Research Laboratories Meiji Seika Kaisha, Ltd.
Year first mentioned:	1979
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC(C1CCC(C(O1)OC2C(C(C(C(C2O)N(C)C(=O)CN=CN)OC)O)N)N)N
Isomeric SMILES:	CC(C1CCC(C(O1)OC2C(C(C(C(C2O)N(C)C(=O)CN=CN)OC)O)N)N)N
InChI:	InChI=1S/C18H36N6O6/c1-8(20)10-5-4-9(21)18(29-10)30-16-12(22)14(26)17(28-3)13(15(16)27)24(2)11(25)6-23-7-19/h7-10,12-18,26-27H,4-6,20-22H2,1-3H3,(H2,19,23)
InChI Key:	VFBPKQSATYZKRX-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/107800

External links:
Guide to Pharmacology:	dactimicin
Main Source:	https://www.jstage.jst.go.jp/article/antibiotics1968/32/12/32_12_1354/_article/-char/en
Citations:	https://pubmed.ncbi.nlm.nih.gov/2506028/ https://pubmed.ncbi.nlm.nih.gov/7192278/