Compound ID | 3150

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Sporaricin A

Class: Aminoglycoside

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Mycobacterium smegmatis, and aminoglycoside-resistant strains of Escherichia coli and Pseudomonas aeruginosa
Description: Natural product from Saccharopolyspora hirsuta subsp. kobensis; shows superior activity compared to amikacin in mice infected with Staphylococcus aureus, Escherichia coli, or Klebsiella pneumoniae
Institute where first reported: Tokyo Research Laboratories, Kowa Co., Ltd.
Year first mentioned: 1979
Development status: Experimental
Chemical structure(s):
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Molecular weight: 389.49
Iso. SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)N(C)C(=O)CN)OC)N)N)N
InChI Key: VMUGJEXITMIYRW-UHFFFAOYSA-N
Can. SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)N(C)C(=O)CN)OC)N)N)N
InChI: InChI=1S/C17H35N5O5/c1-8(19)11-5-4-9(20)17(26-11)27-16-10(21)6-12(25-3)14(15(16)24)22(2)13(23)7-18/h8-12,14-17,24H,4-7,18-21H2,1-3H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/194399
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/32/3/32_3_173/_article

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